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1 Kgp is a cysteine protease virulence factor secreted by Porphyromonas gingivalis, a keystone bacterium in the development of periodontal disease. 2 The secretion of gingipain proteases is part of the asaccharolytic metabolism of P The third Cortexyme presentation, titled "COR388 (atuzaginstat), a novel gingipain inhibitor, decreases ApoE fragmentation in the CNS of Alzheimer’s disease patients" (Abstract 40578P3 The Phase I clinical trial designed to examine safety and tolerance of CO4388 was completed in October of 2018. The Phase 1 study enrolled 33 subjects into 4 different cohorts. One of the cohorts enrolled 9 Alzheimer’s disease patients, and 6 of these patients received the small-molecule gingipain inhibitor … 2021-2-15 · The GAIN (GingipAIN Inhibitor for Treatment of Alzheimer’s Disease) Trial is a randomized, double-blind, placebo-controlled Phase 2/3 trial evaluating the efficacy, safety, and tolerability of A Novel Approach to the Treatment of Alzheimer’s Disease. GAIN is based on the growing body of scientific evidence that the bacteria P. gingivalis can infect the brain and cause Alzheimer’s disease.. This clinical trial will evaluate whether Cortexyme’s investigational bacterial protease inhibitor COR388 (atuzaginstat) is safe and effective at halting or slowing the progression of No, we don’t know that gum disease causes Alzheimer’s A new study suggests a link between oral bacteria and Alzheimer’s, but it’s far from proven 2019-3-20 · A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy. FASEB J. 28 , 3564–3578 (2014).
After these positive results data, Cortexyme is planned to do a Phase II/III study called GAIN (GingipAIN Inhibitor for treatment of AD) that will start in Q2 2019 and topline results are expected at the end of 2021. A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy FASEB J. 2014 Aug;28(8):3564-78. doi: 10.1096/fj.14-252130. Epub 2014 Apr 28. Authors Shinsuke Kataoka 1 COR388, a novel lysine‐gingipain inhibitor, is currently being tested in a Phase 2/3 clinical trial to target Pg for the treatment of AD. Based on the current preclinical data reported here, COR388 has the potential to attenuate atheroma formation and systemic inflammation in Pg‐ induced atherosclerosis and therefore may have beneficial Remember, gingipains are proteases, meaning they like to chop up proteins. It turns out the gingipains are cleaving – chopping up – the tau proteins into fragments.
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The investigators, including Stephen Dominy, MD, the chief scientific officer of Cortexyme, which has developed a gingipain inhibitor, CORE-388, identified the pathogen in the brains of patients with Alzheimer disease, as well as the organism’s gingipains—lysine-gingipain (Kgp), arginine-gingipain A (RgpA), and arginine-gingipain B (RgpB)—in the neurons of these patients. 2020-7-28 · COR388 (atuzaginstat), a novel gingipain inhibitor, decreases ApoEfragmentation in the CNS of Alzheimer’s disease patients.
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They showed that P. gingivalis developed rapid resistance to moxifloxacin, a broad-spectrum antibiotic, but not to the Kgp inhibitor COR388.
2020-4-2 · The GAIN (GingipAIN Inhibitor for Treatment of Alzheimer’s Disease) Trial is a randomized, double-blind, placebo-controlled Phase 2/3 trial is evaluating the efficacy, safety, and tolerability of COR388, Cortexyme’s investigational gingipain inhibitor, in patients with mild to moderate Alzheimer…
The GAIN (GingipAIN Inhibitor for Treatment of Alzheimer’s Disease) Trial is a randomized, double-blind, placebo-controlled Phase 2/3 trial evaluating the efficacy, safety, and tolerability of
2021-4-4 · Alzheimer’s disease treatment: GAIN trial.
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Many companies have phase II clinical trials exploring the mABs targeting tau but there are drugs in development targeting tau that are not mABs. Non-amyloid methods also include the gingipain inhibitor (Corteyme -COR388). Gingipains are byproducts of oral bacteria p.
COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria, Porphyromonas gingivalis and Porphyromonas gulae , typically associated with periodontal disease and systemic infections in humans and dogs
COR388, a novel gingipain inhibitor, decreases fragmentation of ApoE in Alzheimer’s disease central nervous system. Submitted Mar 31, 2020.
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Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients. Toxic proteases from the bacterium called gingipains were also Oral administration of gingipain inhibitors to mice with established brain infections decreases the abundance of P. gingivalis DNA in brain and mitigates the neurotoxic effects of P. gingivalis infection. Thus, gingipain inhibition could provide a potential approach to the treatment of both periodontitis and AD. The third Cortexyme presentation, titled “COR388 (atuzaginstat), a novel gingipain inhibitor, decreases ApoE fragmentation in the CNS of Alzheimer’s disease patients” (Abstract 40578P3), presents Oral administration of gingipain inhibitors to mice with established brain infections decreases the abundance of P. gingivalis DNA in brain and mitigates the neurotoxic effects of P. gingivalis infection. Thus, gingipain inhibition could provide a potential approach to the treatment of both periodontitis and AD. 1 INTRODUCTION This small molecule gingipain inhibitor is atuzaginstat, and it's being studied by CRTX in late stage studies in periodontitis and Alzheimer’s, the latter is, of course, the value driver. Pipeline The third Cortexyme presentation, titled “COR388 (atuzaginstat), a novel gingipain inhibitor, decreases ApoE fragmentation in the CNS of Alzheimer’s disease patients” (Abstract 40578P3), presents data indicating P. gingivalis gingipains target and cleave ApoE proteins in the nervous system of AD patients.